Jul
15
OVER-THE-COUNTER,
THROUGH THE MAIL REMEDIES
Up to two years ago there had been a thriving over the counter and through the mails business of selling non-prescription compounds and “cures” and treatments for BPH.
Several years ago the Post Office Department began challenging many of these products sold through the mail on grounds that they were advertised misleadingly, and that they did not do what they claimed to do. Simple misrepresentation which could ban them from the mail.
That campaign by the U.S. postal authorities put a lot of people out of business who were selling various mail order non-prescription products to treat the prostate.
In March of 1990, the Food and Drug Adminstration said it would ban the sale of all non-prescription drugs used to treat enlargement of the prostate gland. The FDA said their review of the products found little evidence that any of them eliminated, arrested or treated the condition called benign prostatic hypertrophy. There was no date given for enforcing the ban or activating it.
The FDA, evidently not keeping up with current developments in the field, said surgery was the only effective treatment for BPH. A lot of urologists and specialists in the drug field will argue long and hard with their dictum with the various minor-surgical techniques we’ve discussed so far and the new drugs being developed.
What the FDA order does is ban non-prescription products that are advertised for the treatment of the prostate. They did not, and can not ban the sale of certain chemicals or compounds that have been considered by many since the Feinblatt/Gant study in 1958, to be beneficial to reduce BPH symptoms. These chemicals, mainly amino acids, are used in many of the soon to be banned products.
The study was conducted by Dr. Henry M. Feinblatt and Dr. Julian C. Gant and reported in the Journal of the Maine Medical Association in March of 1958, Volume 49, Number 3.
The study deals with the “Value of glycine, alanine and glutamic acid combination,” in the treatment of BPH.
These three chemicals have generally been used by dozens, perhaps hundreds of non-prescription compounds aimed at the general public since 1958.
Were these remedies straight out of the Wild West’s Medicine Man’s wagon of hokkum, or do they have some beneficial results that the traditionalist medical men on the FDA panels refuse to recognize?
Let’s look at the Feinblatt/Gant study that started it all.
The doctors had been using these three amino acids to treat their allergy patients. One of the patients mentioned that his urinary problems had improved since he’d been taking the medications from the doctors.
This stirred their imagination and the two medical men decided to try the three way amino acid combination on a group of non-allergy patients. The tests proved that these BPH sufferers had a dramatic relief from their urinary and BPH symptoms.
They moved from there to a clinically stringent test. A group of 40 patients with benign prostatic hyperplasia were treated with glycine-alanine-glutamic acid capsules for three months.
The patient age range was from 37 to 75 years and weigh from 101 to 192 pounds. BPH complaints ranged in duration at the start of the test from one to six years by various patients.
Placebo capsules were given to half of the patients and the amino acids to half. The patients response results over three months were charted. (Understand here that most such tests should be conducted over six months for best reliability.)
Results of the clinical tests were published in this way. For the control group taking the amino acids, the doctors said the size of the prostate was reduced in 92% of the cases. Nocturia was relieved in 95% of cases. Urgent urination was relieved in 81% and frequency in 73%. Discomfort was reduced in 71% of the cases. No such results were observed in the placebo taking control patients.
Other medical authorities have conducted tests along the same lines to confirm or deny the Feinblatt/Gant findings.
In the Journal of the American Geriatrics Society in 1962, Dr. Frederick Damrau of New York City reported such a test. His conclusions were similar. He said the combination of the three amino acids were used in a controlled cross-over test in forty cases of BPH. After three months on the test the patients reported nocturia was relieved or reduced in 95% of cases, urgency down in 81%, frequency lowered in 73% and delayed urination in 70%. Dr. Damrau said there were no adverse side effects or adverse reactions to the amino acids.
Other evidence the FDA ignored or discounted comes from Japan where a series of nine clinical tests were conducted at the department of urology of Kyoto University in Kyoto.
Some of these tests were double blind, which means there was no way the participants could have any idea if they were receiving the test material or a placebo.
The tests were published in the Acta Urological Japonica, volume 14, 1968.
Results for the amino acids therapy for hypertrophy of the prostate showed that the glycine-alanine-glutamic acid capsules were administered to thirty six cases of diagnosed uncomplicated BPH. The capsules gave satisfactory results in relieving subjective and objective symptoms and no side effects were observed in any of the patients.
In another of the tests, statistical results showed that improvement of symptoms were as follows:
• Urinary frequency reduced in 77.7%
• Nocturia relieved in 68.4%. Difficulty of urination relieved 77.3%
• Feeling of residual urine relieved in 71.4% Side effects were found in only one case and that was relieved with a gastrointestinal drug.
Now, one of the obvious questions is this: If these amino acids are so good, as these tests tend to show, why hasn’t one of the huge pharmaceutical giants leaped on the band wagon and brought out a tested, recognized and approved by FDA combination of these amino acids for the prostate sufferers?
The logical answer could be that their own testing did not match the results of the tests shown above. Or, the situation may be that the amino acids would not be a “proprietary” compound that they could patent, protect and profit from. It would be similar to spending millions to test a salt pill, and bring it out only to find that every othercompany could make the same salt pill.
Jul
7
BENIGN PROSTATIC HYPERPLASIA (BPH). SYMPTOMS OF AN ENLARGED PROSTATE.
July 7, 2009 | Leave a Comment
SYMPTOMS OF AN ENLARGED PROSTATE
Do you have any of the symptoms of an enlarged prostate? Here is a list of those problems that relate directly to BPH. Study the list critically. Have you experienced any of them?
• A slowing of your urinary stream and its force.
• A slowness to begin urination. You say “start now,” but it may be a few seconds before your stream begins.
• A problem with stopping urination. You tighten the muscles to stop the flow or to prevent any more, but you get a series of continuing dribbles.
• A sensation that your bladder is not completely empty when it should be.
• Frequent urination. You may not notice this during the day, especially if you’re near a bathroom. But at night this is much more evident. Doctors call this nocturia, and it may get you up two, three, four times a night.
• In extreme cases, urinary retention — when you simply can’t urinate. The discomfort and pain can be tremendous.
• Nausea, dizziness, unusual sleepiness brought on if retention has caused kidney damage.
A SIMPLE TEST YOU CAN GIVE YOURSELF
Below is a chart with the symptoms listed above. Some of them are worded differently. At the top are the points to be given for each symptom and its severity. Along the left side are the symptoms.
TOTAL SCORE
POINTS 0 1 2 3 4
STREAM Normal Variable Weals Dribbling
Abdominal
VOIDING No Strain strain or re”
HESITANCY None Yes
INTERMITTENCY None Yes
BLADDER Don’t know Variable Incomplete Single Repeated
EMPTYING or Complete retention
Yee ii ,Wd .9 INCONTINENCET— =
URGE None Mild Moderate Savers
tlmo-d~)
NOCTURIA 0-1 2 3-4
DIURIA ci>llh q2-3h qt-2h ci<lh
Intermittency means that your stream starts, stops and starts again once or more before you feel empty. Incontinence means that you can’t stop urinating when you want to, or you dribble, or pass some water when you don’t want to.
Diuria, means how often your need to urinate during the day. Zero points for three hours or more and 3 points for the need to void each hour during the day.
Mark down what you think your symptoms are. If your score reaches 10 or more, you should probably see your doctor soon about the chances you have BPH.
Jul
7
BENIGN PROSTATIC HYPERPLASIA (BPH)
Benign Prostatic Hyperplasia, sometimes called Hypertrophy, is the medical way of saying that the prostate gland has enlarged. In early stages this enlargement may not cause any problems. As it enlarges more and more with a man’s increasing age, it may squeeze the urethra smaller and smaller.
This reduces the force and size of your urine stream, and if left untreated, BPH could lead to the closure of the urethra resulting in severe sickness and even death.
Doctors say that in BPH the glandular tissue within the prostate capsule enlarges, grows, and no one seems to know why it happens or how to prevent or stop this growth.
This is a benign growth. That means it is not cancerous, it does not spread to other parts of the body or attack other tissues or cells. If it were malignant, as in cancer of the prostate, it would destroy and attack other tissue or cells and spread.
In the drawings here, notice how the urethra is fully open in the first one. It passes through the prostate allowing normal flow of urine from the bladder through the urethra and out the penis.
In the second drawing, the darker growth of benign tissue has begun and already has taken the bulge out of the urethra. In the third drawing, the BPH tissue has almost closed the tube the urine must pass through, making urination extremely difficult and bringing on all sorts of BPH symptoms and problems.
We come back to the apple example. Your prostate is like an apple with the core taken out. Through the core goes the urethra. The size of the urethra may begin to shrink when the prostate starts to enlarge when most men are about forty to forty-five. Often by the time a man is in his fifties he’s noticing some changes in his urination pattern.
It is just outside the urethra where the benign growth of the prostatic tissue begins, and it usually grows in both directions, which at once impacts the size of the urethra.
The growth of the tissue usually is not uniform or consistent all along the urethra. It may develop in one section and not in another, so the urethra is not compressed all along its length, at least not at first.
However, as with any tube or a garden hose, pressure at any one spot can shut off the tube entirely and cause all sorts of problems.
The new growth in the prostate consists of the same types of tissue as the normal prostate gland has, but in different proportions. The new, benign growth is going to have more of the glandular type of tissue.
The new growth in the prostate usually develops in both an inward and outward direction, toward the urethra and toward the exterior of the gland. When it grows outward it compresses the normal prostatic tissue against the sturdy outer capsule of the prostate.
When this outer growth takes place in the two lobes of the prostate nearest the rectum, a specialist can feel this with a digital examination. The outward growth does not narrow the urethra so there would be none of the usual BPH symptoms.
In most cases, however, when there is an outward growth of the tissue, it also grows toward the inside as well. Now we get the narrowing of the urethra over the years, and the normal symptoms of BPH.
The prostate has several sections, and digital examination can touch only the back part of the prostate. The sections that can’t be felt can harbor benign or malignant growth. This is one of the reasons for other tests for prostatic cancer that we’ll explain in detail later.